Point estimation for adaptive trial designs II: Practical considerations and guidance.

"data s1: supporting information.; data s2: supporting information."

"r code to obtain these estimators is provided in the supporting information.; to do so we used the (asymptotic) canonical joint distribution of the standardized test statistics at each stage which is bivariate normal--for further details see the r code included in the supporting information. r code to obtain these estimators is provided in the supporting information.; see also the r code provided in the supporting information.; r code for calculating the ses is given in the supporting information.; to do so we used the (asymptotic) canonical joint distribution of the standardized test statistics at each stage which is bivariate normal--for further details see the r code included in the supporting information."

"This research was supported by the NIHR Cambridge Biomedical Research Centre (BRC‐1215‐20014). This report is independent research supported by the National Institute for Health Research (Prof Jaki's Senior Research Fellowship, NIHR‐SRF‐2015‐08‐001). The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health and Social Care (DHCS). T Jaki and DS Robertson received funding from the UK Medical Research Council (MC_UU_00002/14). DS Robertson also received funding from the Biometrika Trust. B Choodari‐Oskooei was supported by the MRC grant (MC_UU_00004_09 and MC_UU_12023_29). The Centre for Trials Research receives infrastructure funding from Health and Care Research Wales and Cancer Research UK."