Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours.

"data availability raw and processed 3'mrna sequencing data generated in this study have been deposited in the gene expression omnibus database under accession code gse216043 .; the raw and processed dna sequencing data (crispr/cas9 screen) are available in the gene expression omnibus database under accession code gse225852 . a complete list is provided in supplementary fig s4 and supplementary data set s1 .; to further investigate the molecular mechanisms of mln4924 and cisplatin treatment in tgcts the transcriptome of 2102ep as well as jar cells was analysed by 3'mrna sequencing after 2 days of treatment (supplementary data set s1 ). data availability raw and processed 3'mrna sequencing data generated in this study have been deposited in the gene expression omnibus database under accession code gse216043"

"Competing interests The authors declare no competing interests."

"Funding Open Access funding enabled and organized by Projekt DEAL."