Development of mouse models with restricted HLA-B∗57:01 presentation for the study of flucloxacillin-driven T-cell activation and tolerance in liver injury.

"Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest."

"Supported by the US Food and Drug Administration (FDA) Intramural Research Program, and in part by a Postgraduate Research Fellowship Award to K.K.S., S.S., and H.A. from the Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement between the US Department of Energy and the FDA. We thank Janet Woodcock, former director of the Center for Drug Evaluation and Research (CDER, FDA), for her support of this project. We also wish to thank the personnel of the Division of Veterinary Services (FDA) for care of the mice. We thank David Hone, Weiming Ouyang, and Joao Pedras Vasconcelos for critically reading drafts of the report."