Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation.

"Declarations Ethics approvalNo patient data or clinical studies were included in this manuscript. All animals involved in our research were cared under the provision and suggestions of the Chinese Experimental Animals Administration Legislation. The experiment procedures were approved by the Animal Protection and Use Committee of Huazhong University of Science & Technology. Competing interestsThe authors declare no conflict of interest. Competing interests The authors declare no conflict of interest."

"This study was supported in parts by grants from the Natural Science Foundation of China (91949205, 31730035, 81721005, 82071219), Guangdong Provincial Key S&T Program (018B030336001), the Special project of technological innovation of Hubei Province (2018ACA142), the China Human Brain Bank Consortium, the Hubei Province scientific research project (WJ2021M041), the Wuhan Health Science Foundation (WX20Q04). We thank Longyu Ma and Huiyun Du, Meifang Ma and Yuanhao Li for technological assistance in electrophysiological experiment. Thanks to Fei Xu for enlightening my present and future."