Aging-related volume changes in the brain and cerebrospinal fluid using artificial intelligence-automated segmentation.

"Declarations GuarantorAs this is a multi-center study conducted by the heads of respective institutions, the guarantors of the study are the co-authors. The first and corresponding author, Shigeki Yamada, who is assistant professor (lecture) at the Department of Neurosurgery, Shiga University of Medical Science, will be the primary contact in case of questions. Conflict of interestSY has a joint research agreement with FUJIFILM Corporation and has received research funding. He has received honoraria for lectures from FUJIFILM Medical Corporation. No developers from FUJIFILM Corporation are included as co-authors. The remaining authors declare no relationships with any companies whose products or services may be related to the subject matter of the article. Statistics and biometrySY has significant statistical expertise. He learned biostatistics at the department of the Health and Environmental Sciences, Kyoto University School of Public Health from 2001 to 2004. Since 2003, he was responsible for statistical analysis in more than 30 major papers. Informed consentHealthy volunteers underwent MRI after providing written informed consent explaining the potential for detection of brain disease. Ethical approvalInstitutional Review Board approval was obtained. The study design and protocol have been approved by the ethics committee at Shiga University of Medical Science on October 11, 2019 (IRB number: R2019-227). The MRI data in this study is not available to the community via any open repositories, because the ethics committees have approved that this research shares MRI data with five collaborative institutes and does not allow it to be provided to other institutions. The data will only be available if the ethics committees approve new participation in the collaborative research. Study subjects or cohorts overlapStudy subjects in this study did not overlap in our previous publications. All contents in this manuscript have not been published or presented elsewhere in part or entirety and is not under consideration by another journal. Methodology• prospective• observational/cross sectional study• performed at one institution Conflict of interest SY has a joint research agreement with FUJIFILM Corporation and has received research funding. He has received honoraria for lectures from FUJIFILM Medical Corporation. No developers from FUJIFILM Corporation are included as co-authors. The remaining authors declare no relationships with any companies whose products or services may be related to the subject matter of the article."

"Funding This research has received research grants from the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research (A) for 4 years, beginning in 2022 (Grant no. 22H00190); Scientific Research (B) for 3 years, beginning in 2022 (Grant no. 22H03020); Scientific Research (C) for 3 years, beginning in 2021 (Grant no. 21K09098); and Scientific Research (C) for 3 years, beginning in 2022 (Grant no. 22K09289). In addition, this research was supported by FUJIFILM Corporation for 4 years, beginning in 2019, G-7 Scholarship Foundation for 1 year in 2020, Osaka Gas Group Welfare Foundation for 1 year in 2022, Taiju Life Social Welfare Foundation for 1 year in 2020, and for 1 year in 2022. The funders had no effect or involvement in the writing of this article. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."