rAAV-PHP.B escapes the mouse eye and causes lethality whereas rAAV9 can transduce aniridic corneal limbal stem cells without lethality.

Authors:
Mirjalili Mohanna SZ; Korecki AJ; Simpson EM.

Journal:
Gene Ther

Publication Year: 2023

DOI:
10.1038/s41434-023-00400-6

PMCID:
PMC10506911

PMID:
37072572

View on PubMed View on PMC View Publisher
Journal Information

Full Title: Gene Ther

Abbreviation: Gene Ther

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Genetics, Medical

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

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Transparency Score
4/6
66.7% Transparent
Transparency Indicators
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Core Indicators
Evidence found in paper:

"data availability the raav genome plasmid used in this study (pems2118"

Code Sharing
Evidence found in paper:

"Competing interests The authors declare no competing interests."

Evidence found in paper:

"Funding This work was primarily funded by a Canadian Institutes of Health Research grant (PJT-159484). Additional financial support was received from Fighting Blindness Canada. The Phoenix Micron Anterior Segment Imaging system and SommoSuite were funded by the Canada Foundation for Innovation (35143), British Columbia Knowledge Development Fund, and British Columbia Children’s Hospital Research Institute (BCCHRI) (CRG74760)."

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Open Access
Paper is freely available to read
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Tool: rtransparent

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Last Updated: Aug 05, 2025