Enhanced in vivo and ex vivo thrombin generation after lower-leg trauma, but not after knee arthroscopy.

"Declarations Ethics approval and consent to participateThe POT-CAST and POT-KAST trials were both approved by the Medical Ethics Committee of Leiden University Medical Center. In both trials, all participants provided written informed consent for participation. The ClinicalTrials.gov Identifiers of the trials are NCT01542762 (POT-CAST) and NCT01542723 (POT-KAST). Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding The authors received no specific funding for this work. The original trials on which the present study is based, i.e., the POT-(K)CAST trials, were funded by the Netherlands Organization for Health Research and Development."