Triple modality image reconstruction of PET data using SPECT, PET, CT information increases lesion uptake in images of patients treated with radioembolization with [Formula: see text] micro-spheres.

"availability of data and materials the triple modality acquisition of the nema data is available at https://osf io/pcfb4/ . availability of data and materials the triple modality acquisition of the nema data is available at https://osf"

"code availability all reconstruction algorithms used in the manuscript are freely available in https://github com/ucl/stir git and the synergistic image reconstruction framework ( https://github com/synerbi/sirf git )."

"Declarations Ethics approval and consent to participateFor retrospective studies on anonymous imaging data of this nature, no informed consent or ethical approval was required. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by the National Measurement System of the UK’s Department for Business, Energy and Industrial Strategy and GE Healthcare. Software used is part-maintained by CCP SyneRBI, funded by the UK EPSRC (Grant EP/T026693/1). Staff at the Institute of Nuclear Medicine are supported by the NIHR UCLH Biomedical Research Centre."