An interferon gamma response signature links myocardial aging and immunosenescence.

"data availability the raw and processed single-cell rna-sequencing data presented in this study has been deposited in the ncbi gene expression omnibus (geo) database under the accession number gse217098. data availability the raw and processed single-cell rna-sequencing data presented in this study has been deposited in the ncbi gene expression omnibus (geo) database under the accession number gse217098"

"Conflict of interest: None declared."

"Funding This work was supported by the German Research Foundation (DFG grant 411619907 to G.C.R. and 471241922 to KSB) and the European Research Area Network—Cardiovascular Diseases (ERANET-CVD JCT2018, AIR-MI Consortium grants 01KL1902 to G.C.R.). G.C.R. and C.C. were supported by the Interdisciplinary Centre for Clinical Research Würzburg (E-354 to G.C.R., E-353 to C.C.). G.C.R., C.C., E.A.S., U.H., J.D. and S.F. lead projects integrated in the Collaborative Research Centre ‘Cardio-Immune interfaces’, funded by the German Research foundation (SFB1525 grant number 453989101). R.S. was supported by a Humboldt Research Award from the Alexander von Humboldt Foundation and by the Canadian Institutes for Health Research (Foundation grant award 143299). This work was supported by the Core Unit Systems Medicine and by the Interdisciplinary Center for Clinical Research of the University Hospital Würzburg grant IZKF-Z6."