Lower vs Higher Fluid Volumes in Adult Patients With Sepsis: An Updated Systematic Review With Meta-Analysis and Trial Sequential Analysis.

"Financial/Nonfinancial Disclosures The authors have reported to CHEST the following: The authors are involved in a multicenter international randomized clinical trial (The Conservative vs Liberal Approach to fluid therapy of Septic Shock in Intensive Care [CLASSIC]; Clinicaltrials.gov identifier NCT03668236) included in the review and funded by the 10.13039/501100009708Novo Nordisk Foundation (NNF17OC0028608) and by the Sofus Friis Foundation. P. B. H., M. H. M., J. W., and A. P. were involved in the planning and conducting of the CLASSIC pilot randomized clinical trial. M. K. J., T. S. M., M. C., and P. B. H. are the first authors in four of the trials included in the present review."

"Funding/Support P. S. receives funding from the Research Council of Rigshospitalet, Copenhagen, Denmark; and the Ehrenreich Foundation. The Department of Intensive Care, Rigshospitalet receives support for research projects from Fresenius Kabi, Pfizer (CP231465), and Sygeforsikringen ‘danmark’ (2020-0320) and conducts contract research for AM-Pharma."

"Trial Registration PROSPERO; No.: CRD42022312572; URL: https://www.crd.york.ac.uk/prospero/"