A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses.

"mapped genes/loci region gene functions snp outcome pmid comments dcc nociceptive pathways rs4384683 rs62098013 rs72922230 rs17748074 18:50442591_tttc_t chronic back pain multisite chronic pain chronic back pain cipn multisite chronic pain 30261039 31194737 33021770 28317148 33830993 * * * + * falec; adamtsl4 nervous system development ( adamtsl4 ) rs59898460 rs367563576 rs59898460 multisite chronic pain chronic back pain multisite chronic pain 31194737 33021770 33830993 * * + * + ca10; linc01982 brain development ( ca10 ) rs12453010 rs11079993 rs11079993 shoulder and neck pain multisite chronic pain multisite chronic pain 32246137 33830993 31194737 * * + * exd3 cell-cycle progression rs73581580 rs73581580 rs73581580 multisite chronic pain genetic components of chronic musculoskeletal pain multisite chronic pain 31194737 32587327 33830993 * * * + foxp2 brain development rs12537376 rs2049604 rs12705966 multisite chronic pain shoulder and neck pain genetic components of chronic musculoskeletal pain 31194737 32246137 32587327 * * * lrp12; zfpm2 internalization of lipophilic molecules ( lrp12 ) rs2941627 rs3110366 rs3110290 cipn cipn cipn 22843789 32562552 28611204 tspan2; ngf regulation of cell development activation growth and motility ( tspan2 ) sensory neurons growth and differentiation ( ngf ) rs7523831 rs12030576 rs7523086 dysmenorrhoea pain dysmenorrhoea pain dysmenorrhoea pain 28447608 29855537 27454463 slc39a8 inflammation rs13135092 rs13107325 rs13135092 multisite chronic pain genetic components of chronic musculoskeletal pain multisite chronic pain 31194737 32587327 33830993 * * * + sox5 chondrogenesis rs12310519 rs12310519 rs12308843 chronic back pain chronic back pain chronic back pain 30261039 30747904 33021770 * * * + abcc4 prostaglandins transportation rs4584690 rs4773840 acute post-radiation therapy pain postherpetic neuralgia 31196165 33685280 linc01065; linc00558 not known rs1443914 rs34003284 multisite chronic pain multisite chronic pain 31194737 33830993 * * + rnf123; amigo3; gmppb brain development synapse assembly ( amigo3 ) cell cycle progression ( rnf123 ) rs7628207 rs1491985 rs7628207 genetic components of chronic musculoskeletal pain chronic widespread pain multisite chronic pain 32587327 33926923 31194737 * * * c6orf106 inflammation rs6907508 rs151060048 multisite chronic pain multisite chronic pain 31194737 33830993 * * + c8orf34 not known rs1865442 rs7834973 chronic back pain chronic back pain 30747904 33021770 * * + ccdc26; gsdmc lumbar disc degeneration rs7814941 rs7833174 chronic back pain chronic back pain 30747904 30261039 * * epha3 nervous system development rs13093031 rs112990863 opioid analgesia neuropathic pain 29502940 34854908 mir4268; epha4 nervous system development ( epha4 ) rs17348202 rs10194315 cipn chronic postoperative pain 23776197 31903573 faf1 apoptosis rs10888692 rs35072907 multisite chronic pain multisite chronic pain 31194737 33830993 * * + fgd4 peripheral nerve pathophysiology rs10771973 rs10771973 cipn cipn 22843789 32562552 gdf5 osteoarthritis rs143384 rs143384 chronic knee pain genetic components of chronic musculoskeletal pain 31482140 32587327 * * linc00290 not known rs12501594 rs6552496 cipn cipn 34391895 28317148 nav3 predominantly expressed in the nervous system rs300501 rs118184265 crps chronic postoperative pain 28025368 31903573 slc24a3 electrical conduction rs2424248 20:19709268_aaaat_a multisite chronic pain multisite chronic pain 31194737 33830993 * * + sox6 chondrogenesis rs4757366 rs61883178 cipn multisite chronic pain 28611204 31194737 * spock2 neurogenesis rs1678626 rs3180 chronic back pain chronic back pain 33021770 30747904 * + * fcgbp maintenance of the mucosal structure rs234348 rs17796312 opioid analgesia chronic widespread pain 24909733 22956598 loc102546299; linc01947 not known rs7734804 rs10515902 post-operation neuropathic pain opioid analgesia 28051079 24909733 mir4422hg; linc01753 not known rs1165472 rs12566055 cipn opioid analgesia 23776197 24909733 gpd2 calcium ion binding and glycerol-3-phosphate dehydrogenase activity rs298235 rs13421094 postoperation neuropathic pain opioid analgesia 28051079 21622719 sp4 dna-binding transcription factor activity rs73271865 rs7798894 temporomandibular disorder multisite chronic pain 28081371 31194737 * * studies included the uk biobank (ukb) as their study cohort and the phenotype definition is based on the pain questionnaires in the ukb (category 100048) + sex-stratified analysis this variant was identified by checking linkage disequilibrium rather than checking gene symbol overlap. details of all loci meeting the inclusion criteria are provided in supplementary data s1 (available as supplemental digital content at http://links lww com/pain/b808 ).; comt is the most investigated candidate gene with 90 published articles followed by sugct (n = 9) and tspan2/ngf (n = 9) (see supplementary data s2 for details of the genes identified in hpgdb available as supplemental digital content at http://links lww com/pain/b808 ).; the functions of these genes are diverse (see supplementary data s3 for details available as supplemental digital content at http://links lww com/pain/b808 ) but many overlapping genes are involved in neurological function such as neurotransmitters ( comt1 ) neuromodulators ( tac1 ) neurotrophins ( efnb2 gfra2 ngf ) and synaptic scaffolding/vesicles ( dtnbp1 ppp1r9b )."

"Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article."

"S. Li was supported by China Scholarship Council (CSC) Grant number 201908130179. S. Li was supported by China Scholarship Council (CSC) Grant number 201908130179."