The tick saliva peptide HIDfsin2 promotes the tick-borne virus SFTSV replication in vitro by enhancing p38 signal pathway.

"Declarations Conflict of interestThe authors declare no competing financial interest. Conflict of interest The authors declare no competing financial interest."

"We thank Professor Xuejie Yu (Wuhan University, China) for gifting the virus strain of SFTSV and Professor Jiahuai Han (Xiamen University, China) for providing the cDNA plasmid of p38α. This research was funded by the joint research fund of the National Science Fund of China—Science and Technology Development Fund of Macau SAR [No. 32161160303 for NSFC and 0010/2021/AFJ for FDCT], National Science Fund of China [No. 32070525], Innovative Research Groups of Hubei Natural Science Foundation [No. 2020CFA015], Fundamental Research Fund for the Central Universities of China [No. 2042021kf0219] and Open Research Fund Program of the State Key Laboratory of Virology of China [No. 2022KF004]."