Obesity alters monocyte developmental trajectories to enhance metastasis.

"all sequencing data have been deposited at the ncbi bioproject resource (prjna954438) with the exception of bulk rna-seq data from mouse lf/hf lung neutrophils which were previously published ( mcdowell et al 2021 ) and can be accessed at the gene expression omnibus ( gse165442 ). data availability data are available upon reasonable request. all sequencing data have been deposited at the ncbi bioproject resource (prjna954438"

"Disclosures: P.O. Fiset reported consulting fees and honoraria from Amgen, BMS, Merck, AstraZeneca, Pfizer, Astellas, Incyte, EMD Serono, and Hoffmann La Roche outside the submitted work. J.D. Spicer reported consulting fees and honoraria from Roche, Merck, AstraZeneca, BMS, Novartis, Chemocentryx, Amgen, Protalix Biotherapeutics, Xenetic Biosciences, and Regeneron and grants to the institution from Roche, Merck, AstraZeneca, BMS, Protalix Biotherapeutics, and CLS Therapeutics. No other disclosures were reported."

"The authors acknowledge funding from the Susan G. Komen Foundation (D.F. Quail), La Vie en Rose (D.F. Quail), Canada Foundation for Innovation (D.F. Quail, L.A. Walsh), Canadian Institutes of Health Research (D.F. Quail, L.A. Walsh), the Terry Fox Research Institute (D.F. Quail), and the Breast Cancer Research Foundation (A.J. Dannenberg). D.F. Quail holds a Tier II Canada Research Chair in Tumour Microenvironment research. L.A. Walsh holds a Rosalind Goodman Chair in Lung Cancer Research. S.A.C. McDowell acknowledges support from the Rosalind Goodman Commemorative Scholarship Charlotte, Michael D’Avirro Scholarship, Leo Karassik Fellowship Foundation, and Canadian Institutes of Health Research Canada Graduate Scholarship. S. Milette acknowledges support from the Canadian Institutes of Health Research Doctoral Fellowship program."