Imbalance of Microbacterial Diversity Is Associated with Functional Prognosis of Stroke.

"Conflicts of Interest The authors declare that there is no conflict of interest regarding the publication of this article."

"This work was supported the National Key Research & Development Program of the Ministry of Science and Technology of the People's Republic of China (Grant numbers 2018YFC2002300 and 2018YFC2002301) and the Nanjing Municipal Science and Technology Bureau (Grant number 2019060002)."

"An individual-center prospective observational case-control research was conducted. Patients were recruited from the regular medical wards or the stroke unit at the Affiliated Lianyungang Oriental Hospital of Kangda College of Nanjing Medical University from 19 January 2022 to 29 July 2022. The inclusion criteria were as follows: (1) age of between 18 years and 80 years, (2) ischemic/hemorrhagic stroke as confirmed by computerised tomography (CT) or magnetic resonance imaging (MRI), and (3) were able to provide a vocal response to the directions they were given and provided informed consent []. Patients were excluded from the study if (1) diagnosed with silent cerebral infarction or transient ischemic attack (TIA), (2) with serious cognitive impairments or mental dysfunctions, and (3) current participation in another clinical trial or participation in another clinical trial in the 6 months prior to enrolment []. Age-, gender-, and risk factor-matching healthy subjects served as the controls. Prior to conducting the study, ethics approval using an approval code was acquired (Institutional Review Board, 2022-041-01). The clinical trial was formally registered in advance with the Clinical Trials Registry (registration number: NCT03938311). Prior to enrolment, consent was acquired with knowledge."