A superior extracellular matrix binding motif to enhance the regenerative activity and safety of therapeutic proteins.

"Competing interests Monash University has filed for patent protection on the molecular design described herein, and Z.J. and M.M.M. are named as inventors. Z.J. and M.M.M are co-founders of Orio Therapeutics, which entered a license agreement with Monash University to secure the exclusive rights to commercialise the technology. The other authors declare that they have no competing interests."

"The authors thank Dr. Michael de Veer at the Monash Bioimaging Facility for support with echocardiogram imaging, Ms. Sin Nee Lau for assistance with histology processing, and Ms. Bhavana Nayer for helping with the intramyocardial injections. Biorender.com was used to create some illustrations in the figures. This work was funded in part by the National Health and Medical Research Council (APP1140229 and APP1176213) to M.M.M, the Viertel Charitable Foundation Senior Medical Researcher Fellowship to M.M.M. and the Swiss National Science Foundation (P2ELP3_175071) to Z.J. The Australian Regenerative Medicine Institute is supported by grants from the State Government of Victoria and the Australian Government."