GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion.

"rna-seq data sets were submitted to the national center for biotechnology information's gene expression omnibus database under the accession number gse139872."

"Duality of Interest. R.J.S. has received research support from Ethicon Endo-Surgery, Zafgen, Novo Nordisk, Kallyope, and MedImmune; has served on scientific advisory boards for Ethicon Endo-Surgery, Novo Nordisk, Sanofi, Janssen, Kallyope, Scohia, and Ironwood Pharma; and is a stakeholder in Zafgen. No other potential conflicts of interest relevant to this article were reported."

"Funding. This research was supported in part by the National Institutes of Health (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant R21 AR067477), National Institute on Aging (grant R01 AG12834 to J.P.K.), National Institute of Diabetes and Digestive and Kidney Diseases (grants R01 DK108089 [to J.P.K.] and R01 DK119188 [to R.J.S.]), National Institute of General Medical Sciences (grant U54 GM104940 to J.P.K.), and UL1 RR024989 (Cleveland, OH). This work was also supported in part by an investigator-initiated award from Crossfit, Inc. (J.P.K.) and a Department of Veterans Affairs grant IK2BX005715 (to N.B.K.). This project used core facilities at Pennington Biomedical Research Center that are supported, in part, by NIH center awards P30GM118430, P20GM135002, and P30DK072476."