Blockade of C5aR1 alleviates liver inflammation and fibrosis in a mouse model of NASH by regulating TLR4 signaling and macrophage polarization.

"transcriptional profiling data were deposited at mendeley data ( https://data mendeley com ) which can easily be accessed at http://dx doi org/10 17632/j8v2c8z7zt 1 raw264 7 cells were kindly provided by kunming cell bank of typical culture preservation committee of chinese academy of sciences kunming china raw264 7 cells were cultured in dulbecco's modified eagle medium (c11995500bt gibico) supplemented with 10% fetal bovine serum."

"Declarations Conflict of interestThe authors declare that they have no conflict of interest. Conflict of interest The authors declare that they have no conflict of interest."

"Funding This study was supported in part by the Natural Science Foundation of Guangxi (2021GXNSFDA075002, 2020GXNSFAA159050), National Natural Science Foundation of China (No. 82160120, 91949122), 111 Project (D17011), Guangxi BaGui Scholars, Advanced Innovation Teams and Xinghu Scholars Program of Guanxi Medical University, Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Gaungxi Medical University), Ministry of Education (GKE-ZZ202114, GKE-ZZ202138)."