Mitochondrial pyruvate metabolism and glutaminolysis toggle steady-state and emergency myelopoiesis.

"all data are available in the ncbi geo (recent ko accession number gse225578 and prolonged ko accession number gse184548 ).; rna-seq data are available in the national center for biotechnology information gene expression omnibus (ncbi geo; recent ko accession number gse225578 and prolonged ko accession number gse184548 ). data availability rna-seq data from fig 5 are available in the ncbi geo. data for recent and prolonged mpc2-deficient gmps are under accession numbers gse225578"

"Disclosures: H.A. Pizzato reported “other” from Sana Biotechnology outside the submitted work. B.N. Finck reported “other” from Cirius Therapeutics during the conduct of the study. G.J. Patti reported a collaborative research agreement with Agilent Technologies and Thermo Fisher Scientific and a financial relationship with Panome Bio. D. Bhattacharya reported personal fees from Clade Therapeutics, GlaxoSmithKline, Gilead Sciences, and Sana Biotechnology outside the submitted work. No other disclosures were reported."

"This work was funded by the National Institutes of Health grants R01AI129945 (D. Bhattacharya), R35ES2028365 (G.J. Patti), and R01DK116746 (M.J. Wolfgang). The development of Mpc2-floxed mice was supported by National Institutes of Health grant R01 DK104735 (B.N. Finck). Open Access funding provided by the University of Arizona."