3-D joint space mapping at the ankle from weight-bearing CT: reproducibility, repeatability, and challenges for standardisation.

"Declarations GuarantorThe scientific guarantor of this publication is Tom Turmezei. Conflict of interestThe authors of this manuscript declare relationships with the following companies: GlaxoSmithKline, Moximed LLC, GE Healthcare, CurveBeam (now CurveBeam AI), and the Standing CT Company. TT has been a paid consultant for GlaxoSmithKline and CurveBeam.JM currently works as Global Development Medical Director (Imaging) at AstraZeneca but was not in this position at the time the study was carried out.MW is a minority shareholder for the Standing CT Company.Jamie Mackay is an editorial board member of European Radiology in the musculoskeletal section. Statistics and biometrySeveral of the authors have significant statistical expertise (Tom Turmezei, Graham Treece). Informed consentAs the site of imaging acquisition, the Royal National Orthopaedic Hospital, Stanmore, UK, exercised discretionary power as a public authority under the GDPR (General Data Protection Regulations) ‘public task’ Article 6(1)(e) to process information from patients with waiver of the requirements for consent or ethics approval given for this study. Ethical approvalAs the site of imaging acquisition, the Royal National Orthopaedic Hospital, Stanmore, UK, exercised discretionary power as a public authority under the GDPR (General Data Protection Regulations) ‘public task’ Article 6(1)(e) to process information from patients with waiver of the requirements for consent or ethics approval given for this study. Study subjects or cohorts overlapN/A Methodology• Retrospective• Observational• Performed at one institution Conflict of interest The authors of this manuscript declare relationships with the following companies: GlaxoSmithKline, Moximed LLC, GE Healthcare, CurveBeam (now CurveBeam AI), and the Standing CT Company. TT has been a paid consultant for GlaxoSmithKline and CurveBeam. JM currently works as Global Development Medical Director (Imaging) at AstraZeneca but was not in this position at the time the study was carried out. MW is a minority shareholder for the Standing CT Company. Jamie Mackay is an editorial board member of European Radiology in the musculoskeletal section."

"Funding Kenneth Poole was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215–20014), but no other authors received any funding for this work."