Astrocytic pathology in Alpers' syndrome.

"Declarations Ethics approval and consent to participateThe study was granted ethical approval for the use of post-mortem tissues from BRAIN UK (19/SC/0217), NBTR (19/NE/0008), EBTB (East of Scotland Research Ethics Service REC1) and NBB. The UK Brain banks are UK Human Tissue Authority-approved and informed consent was obtained. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding RM and RWT are supported by the Wellcome Centre for Mitochondrial Research (203105/Z/16/Z), the Medical Research Council (MRC) International Centre for Genomic Medicine in Neuromuscular Disease (MR/S005021/1), the Mitochondrial Disease Patient Cohort (UK) (G0800674), the UK NIHR Biomedical Research Centre for Ageing and Age-related disease award to the Newcastle upon Tyne Foundation Hospitals NHS Trust, the Lily Foundation, the UK NHS Specialist Commissioners which funds the “Rare Mitochondrial Disorders of Adults and Children” Diagnostic Service in Newcastle upon Tyne, and the Ryan Stanford Appeal who funded a PhD studentship and post-doctoral research associate position awarded to LAS. RWT also receives financial support from the Pathological Society and Mito Foundation. DE is funded by an Alzheimer’s Research UK Senior Fellowship (ARUK-SRF2022A-006)."