Neutrophil extracellular traps and extracellular histones potentiate IL-17 inflammation in periodontitis.

"rna-seq datasets have been deposited in the national center for biotechnology information gene expression omnibus database under accession code gse118166 and gse228021 .; microbiome sequencing data have been deposited to the sequence read archive with the bioprojectid prjna949160 ( http://www ncbi nlm nih gov/bioproject/949160 ).; rna-seq datasets have been deposited in the national center for biotechnology information gene expression omnibus database under accession code gse118166 and gse228021 .; microbiome sequencing data have been deposited to the sequence read archive with the bioprojectid prjna949160 ( http://www ncbi nlm nih gov/bioproject/949160 )."

"Disclosures: The authors declare no competing interests exist."

"We thank all the members of the Moutsopoulos lab for their technical assistance and helpful discussions. We thank the NIDCR Veterinary Resources Core (ZIC DE000740-05); NIDCR/NIDCD Genomics and Computational Biology Core (ZIC DC000086); NIDCR Combined Technical Research Core (ZIC DE000729-09); Genomics Core and the Microbiome and Genetics Core (Center for Cancer Research, National Cancer Institute, National Institutes of Health). This work was supported by the NIDCR and National Institute of Arthritis and Musculoskeletal and Skin Diseases Intramural Research Programs (ZIADE000736 to N.M. Moutsopoulos, Z01DE0699 to T.H. Bugge, 1K99DE030124-01A1 to L.M. Silva, and ZIAAR041199 for M.J. Kaplan). Author contributions: Conceptualization: T.S. Kim and N.M. Moutsopoulos. Experimentation: T.S. Kim, L.M. Silva, V.I. Theofilou, T. Greenwell-Wild, D.W. Williams, T. Ikeuchi, L. Brenchley, NIDCD/NIDCR Genomics and Computational Biology Core, and C. Carmona-Rivera. Data analysis: T.S. Kim, L.M. Silva, T. Greenwell-Wild, C. Carmona-Rivera, and L. Li. Writing the manuscript: T.S. Kim and N.M. Moutsopoulos. Manuscript review/edits: L.M. Silva, D.W. Williams, T. Greenwell-Wild, L. Brenchley, C. Carmona-Rivera, T.H. Bugge, P.I. Diaz, and M.J. Kaplan. Funding acquisition and supervision: T.H. Bugge, L.M. Silva, M.J. Kaplan, and N.M. Moutsopoulos. Overall supervision: N.M. Moutsopoulos."