Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection.

"Conflict of interest: L.V. Wain, M.D. Tobin, I. Sayers and I.P. Hall report collaborative research funding from GSK to undertake the submitted work. L.V. Wain, M.D. Tobin, C. John, A.L. Guyatt and R.J. Packer report funding from Orion Pharma, outside of the submitted work. L.V. Wain reports consultancy for Galapagos. J. Davitte, E. Hessel, D. Michalovich, J.C. Betts and A. Yeo were employees of GSK at the time of this study. D. Michalovich is an employee of Benevolent AI. C.A. Melbourne is an employee of Mirador Analytics. N. Shrine, R. Hall, R. Thompson, A.T. Williams, M.L. Paynton, P.H. Lee, A. Campbell, C. Hayward, M. de Vries, R.J. Allen and J.M. Vonk report no competing interests."

"Support statement: L.V. Wain holds a GSK/Asthma and Lung UK Chair in Respiratory Research (C17-1). M.D. Tobin is supported by a Wellcome Trust Investigator Award (WT202849/Z/16/Z). M.D. Tobin and I.P. Hall hold NIHR Senior Investigator Awards. C. John held a Medical Research Council Clinical Research Training Fellowship (MR/P00167X/1). L.V. Wain, M.D. Tobin, I. Sayers and I.P. Hall report collaborative research funding from GSK to undertake the submitted work. The research was partially supported by the NIHR Leicester Biomedical Research Centre and the NIHR Nottingham Biomedical Research Centre; the views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. This research was funded in part by the Wellcome Trust. We acknowledge the support of the Health Data Research UK BREATHE Digital Innovation Hub (UKRI Award MC_PC_19004). This research was conducted under UK Biobank application 45243. This research used the SPECTRE and ALICE High Performance Computing Facility at the University of Leicester. Generation Scotland received core support from the Chief Scientist Office of the Scottish Government Health Directorates (CZD/16/6) and the Scottish Funding Council (HR03006) and is currently supported by the Wellcome Trust (216767/Z/19/Z). Genotyping of the GS:SFHS samples was carried out by the Genetics Core Laboratory at the Edinburgh Clinical Research Facility, University of Edinburgh, Scotland and was funded by the Medical Research Council UK and the Wellcome Trust (Wellcome Trust Strategic Award “STratifying Resilience and Depression Longitudinally” (STRADL) Reference 104036/Z/14/Z). C. Hayward is supported by a Medical Research Council University Unit Programme grant MC_UU_00007/10 (QTL in Health and Disease). Recruitment to the Generation Scotland CovidLife study was facilitated by SHARE (Scottish Health Research Register and Biobank). SHARE is supported by NHS Research Scotland, the Universities of Scotland and the Chief Scientist Office of the Scottish Government. Funding information for this article has been deposited with the Crossref Funder Registry."