Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration.

"Declarations Ethics approval and consent to participateThe brain bank operates under procedures approved by the Mayo Clinic IRB. The brain autopsy on this patient (Case 1) was performed after consent of the legal next-of-kin. Consent for publicationWe obtained consent for publication from the patient’s family. Competing interestsDr. Russell and Dr. Sandiego are employees of Invicro, LLC. Dr. Navia is employed by APRINOIA Therapeutics. Dr. Golbe has consulted for Amylyx, Apellis, Aprinoia, Mitochon, Mitsubishi Tanabe, P3Lab, Roche, UCB and Woolsey. Dr. Golbe also has served on advisory Boards for Amylyx, Roche and The Rossy Center, and receives travel expenses from CurePSP. Dr. Metrick and Dr. Caughey have applied for patents relating to tau RT-QuIC assays. Competing interests Dr. Russell and Dr. Sandiego are employees of Invicro, LLC. Dr. Navia is employed by APRINOIA Therapeutics. Dr. Golbe has consulted for Amylyx, Apellis, Aprinoia, Mitochon, Mitsubishi Tanabe, P3Lab, Roche, UCB and Woolsey. Dr. Golbe also has served on advisory Boards for Amylyx, Roche and The Rossy Center, and receives travel expenses from CurePSP. Dr. Metrick and Dr. Caughey have applied for patents relating to tau RT-QuIC assays."

"Funding This work is supported by CurePSP, the Rainwater Charitable Foundation and the Intramural Research Program of the NIAID."