Exploring Covalent Bond Formation at Tyr-82 for Inhibition of Ral GTPase Activation.

Authors:
Landgraf AD; Yeh IJ; Ghozayel MK; Bum-Erdene K; Gonzalez-Gutierrez G and 1 more

Journal:
ChemMedChem

Publication Year: 2023

DOI:
10.1002/cmdc.202300272

PMCID:
PMC10529880

PMID:
37269475

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Journal Information

Full Title: ChemMedChem

Abbreviation: ChemMedChem

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Pharmacology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

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"Conflict of interest The authors declare no conflict of interest."

Evidence found in paper:

"The research was supported by the National Institutes of Health (R01CA197928 and R01CA264471) (SOM). The authors gratefully acknowledge use of the Macromolecular Crystallography Facility (MCF) in the Molecular and Cellular Biochemistry Department, Indiana University Bloomington. We also thank Jay Nix for his assistance during X‐ray data collection at beamline 4.2.2 at Advance Light Source (ALS), Berkeley, CA. Buffer and microsomal stability studies were carried out by the Clinical Pharmacology Analytical Core at Indiana University School of Medicine with IU Simon Comprehensive Cancer Center Support Grant P30 CA082709."

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Last Updated: Aug 05, 2025