Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate.

"atomic coordinates and structure factors for both apoe structures were deposited in the protein data bank under the codes8ax8 and 8ax9 respectively.; the mass spectrometry proteomics data have been deposited to the proteomexchange consortium via the pride [ ] partner repository with the dataset identifier pxd036416; username: reviewer_pxd036416@ebi ac uk password: ucotxyam."

"Declarations Ethical approval and Consent to participateNot applicable. Consent for publicationAll authors have approved of the consents of this manuscript and provided consent for publication. Competing interestsJD and ZP are founders of the biotechnology spin-off company Enantis Ltd. The company is not involved in R&D in the domain of Alzheimer’s Disease. Authors’ informationNot applicable. Competing interests JD and ZP are founders of the biotechnology spin-off company Enantis Ltd. The company is not involved in R&D in the domain of Alzheimer’s Disease."

"Funding The authors would like to express their thanks to the Czech Ministry of Education, Youth and Sports (INBIO - CZ.02.1.01/0.0/0.0/16_026/0008451, ENOCH - CZ.02.1.01/0.0/0.0/16_019/0000868, RECETOX RI - LM2023069, ELIXIR - LM2018131, e-INFRA CZ - LM2018140) and Czech Science Foundation (M.M. and L.H. GA22-09853S; D.B. GA21-21510S) for financial support. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 857560 TEAMING. This project has received funding from the European Union’s Horizon Europe program under the grant agreement No 101087124. This research has received funding from The project National Institute for Neurological Research (Programme EXCELES, ID Project No. LX22NPO5107) - Funded by the European Union – Next Generation EU. The article reflects the author’s view and the Agency is not responsible for any use that may be made of the information it contains. CIISB research infrastructure project (LM2018127) is acknowledged for financial support of the measurements at Biomolecular Interactions and Crystallization (BIC) facility at CEITEC. This work was supported by the Ministry of Health, Czech Republic - Conceptual Development of Research Organization, MH CZ - DRO (MMCI, 00209805)."