A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance.

"Declaration of competing interest The authors declare that there are no conflicts of interest."

"This work is supported by the 10.13039/501100003009Science and Technology Development Fund (Grant Nos.: 0007/2020/A1 and 0020/2022/A1), the 10.13039/501100015249State Key Laboratory of Quality Research in Chinese Medicine, University of Macau (Grant No.: SKL-QRCM(UM)-2020-2022), the 10.13039/501100004733University of Macau (Grant Nos.: MYRG2019-00002-ICMS and MYRG2020-00017-ICMS), 2022 Internal Research Grant of SKLQRCM (University of Macau) (Grant No.: QRCM-IRG2022-011), the 10.13039/501100001809National Natural Science Foundation of China (Grant No.: 22101230), the Natural Science Basic Research Program of Shaanxi (Grant No.: 2021JQ-089), and the 10.13039/501100005230Natural Science Foundation of Chongqing, China (Grant No.: cstc2021jcyj-msxmX0659). Ying-Qi Song: Methodology, Validation, Writing - Original draft preparation, Conceptualization; Guo-Dong Li, Dou Niu, and Feng Chen: Validation, Methodology, Formal analysis; Shaozhen Jing: Software, Formal analysis; Vincent Kam Wai Wong: Resources, Methodology; Wanhe Wang: Resources, Conceptualization, Funding acquisition; Chung-Hang Leung: Supervision, Project administration, Funding acquisition, Conceptualization, Writing - Reviewing and Editing."