Antiviral response and immunopathogenesis of interleukin 27 in COVID-19.

"we also reanalyzed the publicly available rna-seq dataset gse173488 (geo) [ ] which was obtained using human monocyte-derived macrophages (mdms) from healthy donors that were either stimulated with 1 ug of sars-cov-2 spike protein per ml for 4 hours (n = 4) or not stimulated.; the second mrna dataset was the publicly available rna-seq gse176290 (geo) dataset [ ] obtained using monocytes from healthy individuals (n = 9) and patients with moderate (n = 9) or severe (n = 11) covid-19.; we reanalyzed the publicly available rna-seq dataset gse176290 (geo) [ ] which was obtained using monocytes from healthy individuals (n = 9) and patients with moderate (n = 9) or severe (n = 11) covid-19.; we reanalyzed the publicly available rna-seq database gse176290 (geo) [ ] which was obtained using monocytes from healthy individuals (n = 9) and patients with moderate (n = 9) or severe (n = 11) covid-19.; we reanalyzed the publicly available rna-seq dataset gse176290 (geo) [ ] obtained using monocytes from healthy individuals (n = 9) and patients with moderate (n = 9) or severe (n = 11) covid-19.; to determine whether tlr1/2-myd88 induction by sars-cov-2 spike protein (s protein) plays a role in the establishment of the il27-dependent pro-inflammatory and antiviral response in macrophages we reanalyzed a publicly available rna-seq dataset gse173488 (geo) [ ].; we reanalyzed the publicly available rna-seq dataset gse173488 (geo) [ ] which was obtained using human mdms from healthy donors that were stimulated with 1 ug of sars-cov-2 spike protein per ml for 4 hours or not stimulated."

"Declarations Conflict of interestThe authors declare that they have no competing interests. Conflict of interest The authors declare that they have no competing interests."

"Funding Open Access funding provided by Colombia Consortium"