An overview of human single-cell RNA sequencing studies in neurobiological disease.

"kumar et al (2022) o cells with <300 genes or > 5000 genes removed o cells with >20% mitochondrial genes removed gene expression omnibus (geo): gse201048 additional: raw counts and analyzed r objects are also available at https://epicimmuneatlas org/natneu2022 .; zhou et al (2020) o cells with >5% mitochondrial genes removed o cells with <400 genes or > 7000 genes removed murine data: gene expression omnibus (geo): gse140511 human data: ad knowledge portal ( https://adknowledgeportal org ) under study snrnaseqad_trem2 and are also accessible through synapse at https://doi org/10 7303/syn21125841 .; additional: processed data is available at synapse org under the synapse id syn21788402 and can also be explored interactively through the cellxgene platform at https://kampmannlab ucsf edu/ad-brain . associated data used to produce figures are also deposited in the zenodo repository ( https://doi org/10 5281/zenodo 6477100 ). data availability pfisterer et al (2020) o cells with >8% mitochondrial genes removed o doublet cells removed european genome-phenome archive (ega): egas00001002882"

"Declaration of Competing Interest: None."

"Funding This work was supported by the National Institutes of Health grants T32 CA009686 and R01 NS118023."