Combining virtual screening with cis-/trans-cleavage enzymatic assays effectively reveals broad-spectrum inhibitors that target the main proteases of SARS-CoV-2 and MERS-CoV.

"data availability no data was used for the research described in the article. acknowledgements the study research was supported by (most110"

"Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper"

"The study research was supported by Taiwan’s National Science and Technology Council (MOST110-2923-B-039-001-MY3, and MOST111-2923-B-039-001-MY3), and by 10.13039/501100007300China Medical University (CMU111-S-18) and 10.13039/501100004391China Medical University Hospital (DMR-112-115, and DMR-112-149). The study was also supported by the Drug Development Center, 10.13039/501100007300China Medical University, from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the 10.13039/100010002Ministry of Education, Taiwan. The experiments and data analysis were performed in the Department of Medical Laboratory Science and Biotechnology, China Medical University, and also in the Medical Research Core Facilities Center, Office of Research & Development, China Medical University, Taichung, Taiwan. We thank Iona J. MacDonald from China Medical University (Taichung, Taiwan) for her editing of this manuscript."