Evidence of neuroinflammation in fibromyalgia syndrome: a [ 18 F]DPA-714 positron emission tomography study.

"Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article."

"The authors thank April Riddle, Evan Hudson, Jessica Ryan, Ella Wetzel, and Jessica Robinson for assistance with participant screening. The authors acknowledge the assistance of the UAB cyclotron facility for production of [18F]DPA-714. This work was supported by the American Fibromyalgia Syndrome Association, with additional support from NINDS (R01NS109529). This project was not preregistered in an institutional registry. Original data will be made available to researchers upon request and receipt of a data sharing agreement. Data analysis code will be shared freely upon request. This study was registered on clinicaltrials.gov, as stated in the Methods."

"All study procedures were approved by the UAB Institutional Review Board (IRB), and the study was registered on clinicaltrials.gov (NCT03759522). Because this study was an observational study, there was no randomization to treatment groups. The study consisted of a phone screening to determine initial eligibility, followed by an in-person screening visit and a neuroimaging visit. For the screening visit, participants meeting initial criteria attended the UAB Advanced Imaging Facility (AIF) to provide written informed consent, complete questionnaires, undergo urine pregnancy testing, fasting blood draws, and a tender point examination."