Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1.

"nanostring data was analyzed by genomic technology core facility (gtcf) at the university of manchester and is available from the array express repository e-mtab-11105. plotting and statistical analysis was done using r statistical software and the result can be accessed using https://figshare com/s/b27115e18ec570d755a7 immunohistochemistry was done both manually on the bench or on the leica bond rx platform and described in the supplementary methods section."

"Disclosure statement No potential conflict of interest was reported by the author(s)."

"Author contributions: DM, JH, and TI conceptualized and designed the study. DM, LZ, ER, AB, SK, EC, KT, SP, AD, BS, SR, RW performed the experiments. DM, ER, AB, LZ, SK, EC, KT, SP, AD, BS, SR analyzed and interpreted the data (e.g., statistical analysis, computational analysis, and bioinformatics analysis). DM, JH, TMI wrote the original draft of the manuscript. DM, JH, ER, EC, and TMI revised the manuscript. DM, LZ, EC, KT, IGM, JH and TMI reviewed and approved the MS. DM, IGM, JH, and TI edited the document. IGM supplied the DVL3 tumor model. TMI and JH secured the funding for this study."