Pathological ultrastructural alterations of myelinated axons in normal appearing white matter in progressive multiple sclerosis.

"Declarations Ethics approval and consent to participateFresh post-mortem brain tissue samples were obtained from the Netherlands Brain Bank. Informed consent was obtained by the Netherlands Brain Bank and the procedure approved by the Ethical Committee (Amsterdam UMC, The Netherlands). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by the Dutch MS Research Foundation (Stichting MS Research, 18-733c MS, MSCNN project grant and 18-1001 MS, out-of-the-box, made possible by MoveS), and the Stichting de Cock–Hadders (WO). Part of the work has been performed in the UMCG Microscopy and Imaging Center (UMIC), sponsored by IMDAP: EU-REACT European regional development fund funded as part of the Union's response to the COVID-19 pandemic; ZonMW grant 91111.006 and the Netherlands Electron Microscopy Infrastructure (NEMI; NWO 184.034.014)."