DHCR24 reverses Alzheimer's disease-related pathology and cognitive impairment via increasing hippocampal cholesterol levels in 5xFAD mice.

"Declarations Ethics approval and consent to participateThis research project was carried out according to guidelines authorized by Animal Experiment and Use Committee at Shanghai Medical College of Fudan University (Permit No. 20210302–026). Consent for publicationNot applicable. Competing interestsThe authors have declared that no conflict of interest exists. Competing interests The authors have declared that no conflict of interest exists."

"Funding This work was supported by the Shanghai Health and Medical Development Foundation, Shanghai, China (201740209); the Jinshan Hospital affiliated to Fudan University Development Foundation, Shanghai, China (HBXK-2022-2); the National Natural Science Foundation of China (31971110, 32171142); the Shanghai Jinshan District Key Medical Foundation, Shanghai, China (JSZK2015A05 and JSZK2019A06); Open Project of Key Laboratory of Longevity and Aging-related Diseases (Guangxi Medical University), Ministry of Education (KLLAD202201)."