Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes.

"the size of the rectangles is proportional to the number of genes included in each pathway table 1 pathways enriched at all braak lb stages name id corrected p -value 0 vs14 corrected p -value 0 vs5 corrected p -value 0 vs6 direction atp metabolic process go:0046034 6 35e-05 0 008566 0 002539 down signal release from synapse go:0099643 0 0001715 0 02021101 0 02581261 down glycolytic process go:0006096 0 0005491 0 0004233 1 14e-06 down ribonucleoside triphosphate metabolic process go:0009205 0 0006046 0 03603505 0 02070463 down purine ribonucleoside triphosphate metabolic process go:0009205 0 001119 0 01947014 0 009645 down pyruvate metabolic process go:0006090 0 001384 0 002427 5 06e-07 down atp generation from adp go:0006757 0 001465 0 001017 5 10e-06 down purine nucleoside diphosphate metabolic process go:0009135 0 01415693 0 008253 1 18e-05 down purine ribonucleoside diphosphate metabolic process go:0009179 0 01415693 0 008253 1 18e-05 down ribonucleoside diphosphate metabolic process go:0009185 0 02394241 0 02425647 5 85e-05 down adp metabolic process go:0046031 0 02407688 0 002126 1 94e-05 down carbohydrate catabolic process go:0016052 0 04027937 0 0006365 1 78e-05 down pathways enriched at all braak lb stages.; data and code availability rna-sequencing data can be accessed through the gene expression omnibus (accession id: gse216281). code used to analyze rna-sequencing data and to generate figures for the manuscript is available at: https://github com/chiaracapp/transcriptomic-profiling-of-pd-brains git ."

"code used to analyze rna-sequencing data and to generate figures for the manuscript is available at: https://github com/chiaracapp/transcriptomic-profiling-of-pd-brains git ."

"Declarations Conflict or interestThe authors have no competing financial and/or non-financial interests to report. Ethical approvalThe data presented in this article utilized human tissue that was procured via the Netherlands Brain Bank (NBB). The brain bank protocols are in accordance with the ethical standards of our institution and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For all donors, written informed consent for the use of tissue samples and clinical information was collected from the participant or their next of kin. All NBB procedures were approved by the Medical Ethics Committee of the VU University Medical Centre, Amsterdam, and the RNA-seq study was approved by the Regional Committee for Health and Medical Research Ethics, Norway."

"Funding Open access funding provided by University of Oslo (incl Oslo University Hospital)."