A chimeric vaccine protects farmed saltwater crocodiles from West Nile virus-induced skin lesions.

"Competing interests Data included in this publication are based on a patent (WO/2018/176075) on which R.A.H., J.H.-P., J.J.H., H.B.-O., and A.M.G.C. are inventors. S.I. is the proprietor of the Centre for Crocodile Research (Noonamah, Northern Territory, Australia). The remaining authors declare no competing interests."

"We thank the crocodile farm management and staff for providing access to facilities, crocodile hatchlings and feed. This research was funded by the Cooperative Research Centre for Developing Northern Australia (CRC-DNA, 2018-20; S.R.I., J.H.-P., R.A.H., and H.B.-O.), The National Health and Medical Research Council (NHMRC) of Australia (grant no. 1146237. R.A.H., H.B.-O., and J.H.-P), the SVS Bequest Fund (H.B.-O. and G.H.), and a donation from BIOHMPATHOLOGY. G.H. was a recipient of an Australian Postgraduate Scholarship Award (2018–2022), the Adam Gillespie Memorial Scholarship for Animal Husbandry, the IUCN-SSC Crocodile Specialist Group Fritz Huchzermeyer Veterinary Science Student Research Assistance Scheme (FHVS-SRAS), and Fred Z. Eager Award. J.H.-P. is supported by an Advance Queensland Industry Research Fellowship."