Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses.

"data availability the crystal structures of e8 tcr and mr1-ligand complexes have been deposited with the pdb under accessions # 7zt2 7zt3 7zt4 7zt5 7zt7 7zt8 and 7zt9 . complete parameters alongside an exemplar tleap script to use said parameters are deposited on zenodo ( https://zenodo org/record/6651550 ). data availability the crystal structures of e8 tcr and mr1-ligand complexes have been deposited with the pdb under accessions # 7zt2"

"Disclosures: R. Simmons, V. Karuppiah, R. Suckling, M. Hock, and M. Lepore reported personal fees from Immunocore Ltd. during the conduct of the study and personal fees from Immunocore Ltd. outside the submitted work. No other disclosures were reported."

"This work received funding from the Swiss National Foundation 310030-173240 and 310030B-192828, Krebsliga BeiderBasel KLbB-4779-02-2019, Swiss Cancer League KFS-4707-02-2019, Department of Biosystems Science and Engineering at Eidgenössische Technische Hochschule Zürich PMB-02-17 (all to G. De Libero), and from the University of Basel 3MM1055 to A. Chancellor. R.M. Crean’s studentship is funded by the Engineering and Physical Sciences Research Council. M.W. an der Kamp is a Biotechnology and Biological Services Research Council David Phillips Fellow (BB/M026280/1)."