Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease.

"metagenomics shotgun sequencing and rna transcriptomics sequencing data are available under ids:prjna986826 and geo accession:gse236012 respectively."

"Declarations Ethics approval and consent to participateAll the experiments were performed according to the EU Animals Scientific Procedures Act (2010/63/EU) and the German law for the welfare of the animals. All the procedure and methods were approved by the local government authorities (Regierungspräsidium, Tübingen; TVA HG3/18) of the state of Baden-Württemberg, Germany. No patients or human data was used in this study. Consent for publicationAll authors have read the manuscript and approved to be co-authors on the manuscript and have substantial contribution in the manuscript. Competing interestsAll the authors declared that they have no competing interest. Competing interests All the authors declared that they have no competing interest."

"Funding Open Access funding enabled and organized by Projekt DEAL. This research project is an EU Joint Programme—Neurodegenerative Disease Research (JPND) (JPCOFUND_FP-829–047 aSynProtect) and is supported through the funding organization Deutschland, Bundesministerium für Bildung und Forschung (BMBF, FKZ). This research was also supported by the Deutsche Forschungsgemeinschaft, DFG through the funding of the NGS Competent Centre Tübingen (NCCT-DFG). This study was also supported by the Fortüne funds (Fortüne grant No. 2642–0-0), Tübingen university, Tübingen. Funders have no role in the study design and data analysis."