Double Plasma Molecular Adsorption System with Sequential Low-dose Plasma Exchange in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure: A Prospective Study.

"The authors have no conflict of interests related to this publication."

"This study was supported by grants from the National major science and technology project for the prevention and treatment of AIDS and viral hepatitis (2018ZX10302204-002-002 to LP, 2018ZX10302205-002 to CX), Natural Science Foundation of China (No. 81873572 to LP, 82070611 to LP), Guangzhou Science and Technology Plan Projects (201904010442 to CX, 202102010204 to LP), Guangdong Science and Technology Plan Projects (2020A1515010317 to CX), Sun Yat-Sen University Clinical Research 5010 Program (2018009 to CX, 2020007 to LP), and the Five-Year Plan of Third Affiliated Hospital of Sun Yat-Sen University (K00006 to LP). All authors contributed to this study’s concept and design, patient recruitment, and follow-up. had full access to the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis (LW, WX), were responsible for the acquisition, analysis, and interpretation of data (SZ, GL, JL, YZ, YL, LZ, QL, ZG), drafted the manuscript (LW), obtained the funding and took responsibility for the supervision (LP, CX), had access to the study data and reviewed and approved the final manuscript (All authors)."

"Ethical statement: This prospective cohort study was conducted under the Declaration of Helsinki, and the protocol was approved by the Ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University (Approval number: [2020]-02-173-01; Trial registration number: NCT04597164). All patients signed the written informed consent before participating in the study."