The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms.

"availability of data and materials bulk rnaseq data referenced in supplemental fig 9 can be accessed at gene omnibus number gse185407 (dodiya et al 2022) and european nucleotide archive e-mtab-10985 (jiwaji et al 2022). availability of data and materials bulk rnaseq data referenced in supplemental fig 9 can be accessed at gene omnibus number gse185407"

"Declarations Ethics approval and consent to participateThis study does not contain any human data. All experimental procedures were approved by the IACUC office of Northwestern University and the University of Chicago. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding Our source of funding for this project was from Open Philanthropy and the Good Ventures Foundation (to R. Vassar, S. Sisodia). This funding was the primary funding mechanism for the study. S Chandra was supported by F30AG079577 (to S Chandra) and NIGMS T32GM008152 (to Northwestern University Medical Scientist Training Program)."