EP3 signaling is decoupled from the regulation of glucose-stimulated insulin secretion in β-cells compensating for obesity and insulin resistance.

"Disclosure statement No potential conflict of interest was reported by the author(s)."

"The authors wish to thank Kathryn Carbajal, Trillian Gregg, and Helena VanDeusen for their scientific and technical guidance during this work. This work was supported in part by Merit Review Award I01 BX003700(to M.E.K.) and I01 BX005113(to M.J.M) from the United States (U.S.) Department of Veterans Affairs Biomedical Laboratory Research and Development (BLR&D) Service. This work was also supported in part by National Institutes of Health (NIH) grant R01 DK102598 (to M.E.K.), R01 DK113103 and R01 DK127637 (to M.J.M.); American Diabetes Association Grant 1-14-BS-115 (to M.E.K.), and start-up and pilot project funding from the University of Wisconsin-Madison Department of Medicine, Graduate School, and Office of the Provost (to M.E.K. and M.J.M). The study sponsors had no role in the study design; collection, analysis or interpretation of data; the writing of the report; or the decision to submit the paper for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the U.S. Department of Veterans Affairs, or the United States Government."