Amelioration of intestinal barrier function and reduction of blood lead level in adult women with recurrent spontaneous abortion by a novel product of dietary fiber mixture, Holofood.

"Declarations Ethics approval and consent to participateInformed consent was obtained from all subjects using protocols approved by the Ethics Committee of Clinical Research of the Shenzhen Maternity & Child Healthcare Hospital with the number of SFYLS-2020-011. Consent to publishNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding Not applicable."

"From November 2019 to November 2020, this randomized, open-label, parallel-group controlled trial was conducted in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice guidelines, with the clinical trial registration number of ChiCTR1900026336. The present protocol was approved by the Ethics Committee for Clinical Research of the hospital with the number of SFYLS-2020-011. All recruited participants were informed the related risks and complications and signed an informed consent form. Investigators were responsible for data collection and analysis."