The p53 challenge of hematopoietic stem cell gene editing.

"Declaration of interests R.O.B. is a co-inventor of patents on HDR in HSPCs, holds equity in Graphite Bio and UNIKUM Tx, and is a part-time employee of UNIKUM Therapeutics."

"Funding in the Bak Lab is supported by a grant from the Danish health authorities (SST) (4-1612-391/1), the EU Commission in the form of an ERC starting grant (project 101041231, Horizon Europe Pillar I) and a grant from the Horizon Research and Innovation Actions (project 101057438, Horizon Europe Pillar II), a 10.13039/501100003554Lundbeck Foundation fellowship (R238-2016-3349), the Independent Research Fund Denmark (0134-00113B, 0242-00009B, and 9144-00001B), an AIAS-COFUND (Marie Curie) fellowship from the 10.13039/501100009388Aarhus Institute of Advanced Studies (AIAS) co-funded by Aarhus University’s Research Foundation and the European Union’s Seventh Framework Program under grant agreement 609033, the 10.13039/501100009708Novo Nordisk Foundation (NNF19OC0058238 and NNF17OC0028894), 10.13039/100012774Innovation Fund Denmark (8056-00010B), the 10.13039/501100002808Carlsberg Foundation (CF20-0424 and CF17-0129), Slagtermester Max Wørzner og Hustru Inger Wørzners Mindelegat, the 10.13039/501100005747A.P. Møller Foundation, the 10.13039/501100006309Riisfort Foundation, the Agnes and Poul Friis’ Foundation, and a Genome Engineer Innovation Grant from Synthego. The figure was created with BioRender."