TLR7/8 stress response drives histiocytosis in SLC29A3 disorders.

"data availability all the rna sequence data analyzed in this manuscript were deposited in the ncbi gene expression omnibus database under accession number gse234367 . data availability all the rna sequence data analyzed in this manuscript were deposited in the ncbi gene expression omnibus database under accession number gse234367"

"Disclosures: T. Shibata reported non-financial support from Invivogen outside the submitted work. Additionly, T. Shibata has a patent to Human TLR8 Tg pending. K. Miyake reported grants from Daiichi Sankyo Co. Ltd. outside the submitted work. Additionly, K. Miyake had a patent to P2018-193376A issued by The University of Tokyo. No other disclosures were reported."

"This work was supported in part by Japan Society for the Promotion of Science (JSPS)/MEXT KAKENHI grants 16H06388, 21H04800, 22H05184, 22K19424, and JP22H05182 to K. Miyake; 16H02494 to T. Shimizu; 21K15464 to R. Sato; 26293083 to S.-I. Saitoh; 19H03451 and 16K08827 to T. Shibata; and Japan Science and Technology Agency CREST grants JPMJCR13M5 and JPMJCR21E4 to T. Shimizu; the Japan Agency for Medical Research and Development (AMED) grant number JP20ek0109385 to T. Shibata; The Mochida Memorial Foundation for Medical and Pharmaceutical Research to T. Shibata; Joint Research Project of the Institute of Medical Science at the University of TokyoIMSUT; JSPS KAKENHI grant number JP 16H06276 (AdAMS), and AMED grant numbers JP223fa627001 and JP233fa627001 to K. Miyake. Open Access funding provided by The University of Tokyo. Disclosures: T. Shibata reported non-financial support from Invivogen outside the submitted work. Additionly, T. Shibata has a patent to Human TLR8 Tg pending. K. Miyake reported grants from Daiichi Sankyo Co. Ltd. outside the submitted work. Additionly, K. Miyake had a patent to P2018-193376A issued by The University of Tokyo. No other disclosures were reported."