The Double-Layered Structure of Amyloid-β Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization.

"the atomic coordinates and structure factors are deposited in the protein data bank with accession code 7y8q ."

"The authors declare no competing financial interest."

"This work was supported in part by JSPS KAKENHI (Grant Numbers JP19K07041 to M.Y.-U., JP21K06040 to S.G.I., JP21K06118 to H.O., and JP16K05858 and JP19K05552 to K.N.), by JST PRESTO (Grant Number JPMJPR22AC to M.Y.-U.), by Grant-in-Aid for Research in Nagoya City University (Grant Numbers 2212008 and 2222004 to M.Y.-U.), and by Joint Research of the Exploratory Research Center on Life and Living Systems (ExCELLS program Nos. 22EXC338 and 23EXC305 to K.Y.). The computation was performed using Research Center for Computational Science, Okazaki Research Facilities, Japan (Projects: 20-IMS-C155, 21-IMS-C172, and 22-IMS-C186). Solid-state NMR measurements were conducted at the Institute for Molecular Science, supported by Nanotechnology Platform Program “Molecule and Material Synthesis” (JPMXP09S17MS1095, JPMXP09S18MS1055, JPMXP09S18MS1087, and JPMXP09S19MS1049) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan."