Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS.

"the ms proteomics data have been deposited to the proteomexchange consortium ( http://proteomecentral proteomexchange org ) via the pride partner repository [ ] and are available with the dataset identifiers pxd041543 (hipsc-derivewd mns) and pxd042617 ( post mortem samples).; data availability the datasets generated and/or analysed during the current study are available in the pride repository and are available with the dataset identifiers pxd041543 (hipsc-derivewd mns) and pxd042617 ( post mortem samples )."

"Funding Open Access funding enabled and organized by Projekt DEAL. This work was funded by the Else Kröner-Fresenius Stiftung (project Nr. 2019_A111; L.SBN.0162) to AC, which is also supported by the Frick Foundation. TB and AC are supported by the Deutsche Forschungsgemeinschaft (German Research Foundation)—SFB1506 “Aging at interfaces” (project A01). JL and MS received financial support from the “Experimental Medicine” graduate program of the Medical Faculty of Ulm University. This work was also funded by MND Scotland and TENOVUS Scotland to CMH. This work was funded by a Lady Edith Wolfson Junior Non-Clinical Fellowship to ZIL from the MND Association (Laszlo/Oct21/977-799). to maximize chances of cure of this deadly disease."