Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain.

"the tmt mass spectrometry proteomics data have been deposited to the proteomexchange consortium via the pride partner repository with the dataset identifier pxd041332 and 10 6019/pxd041332 and will be publicly available as of the date of publication.; the dia-ms dataset has been deposited in massive ( http://massive ucsd edu ): search dataset identifier msv000092490 ( ftp://massive ucsd edu/msv000092490/ ); proteomexchange dataset identifier pxd043960."

"Declaration of Competing Interest: The authors have no disclosures and declare no conflict of interest."

"This work was supported by funding from National Institutes of Health Grants 1R01MH114908-01 (TCJ), T32GM008424 (JMLG), F31MH117839 (JMLG), R01AG065594 (JWJ) University of Pittsburgh Pharmacology and Chemical Biology Fellowship (JMLG, CAC, William C. deGroat Neuropharmacology Departmental Fellowship), and University of Pittsburgh School of Medicine Research Funds. DIA Mass spectrometry analyses were conducted at the University of Texas Health Science Center at San Antonio (UTHSCSA) Institutional Mass Spectrometry Laboratory, with expert technical assistance of Sammy Pardo and Dana Molleur. The laboratory is supported in part by UTHSCSA and the University of Texas System Proteomics Core Network for purchase of the Orbitrap Fusion Lumos mass spectrometer. The contents of this article are solely the responsibility of the authors and do not necessarily represent the views of the funding agencies. CRediT author statement: Joshua M. Lorenz-Guertin: Conceptualization, Methodology, Writing-Original Draft, Visualization, Investigation, Formal analysis; performed animal work, behavioral assays, biochemistry experiments and analysis, proteomic and bioinformatics analysis. Nadya Povysheva: Conceptualization, Methodology, Writing-Original Draft, Visualization, Investigation, Formal analysis; performed electrophysiology experiments. Caitlyn A. Chapman: Writing - Review & Editing, Visualization, Investigation, Formal analysis; performed biochemistry experiments and analysis, proteomic and bioinformatics analysis. Matthew L. MacDonald: Conceptualization, Methodology, Writing-Original Draft, Investigation; performed SRM and TMT proteomic experiments and analysis. Marco Fazzari: Conceptualization, Methodology, Writing-Original Draft, Investigation; performed small molecule mass spectrometry and analysis. Aparna Nigam: Investigation; performed animal work and assisted with electrophysiology. Jessica L. Nuwer: Writing - Review & Editing, Visualization, Investigation; performed biochemistry experiments and analysis. Sabyasachi Das: Investigation; performed biochemistry experiments and analysis. Megan L. Brady: Investigation; performed animal work, behavioral assays. Katarina Vajn: Formal analysis. Matthew J. Bambino: Formal analysis. Susan T. Weintraub: Methodology, Investigation; performed DIA-MS proteomic experiments and analysis. Jon W. Johnson: Conceptualization, Methodology, Funding Acquisition. Tija C. Jacob: Conceptualization, Methodology, Writing - Original Draft, Writing - Review & Editing, Formal analysis, Supervision, Funding Acquisition."