A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer.

"Competing interests VMM reports consulting or advisory role for Boehringer Ingelheim. SH reports consulting or advisory role for Pierre Fabre, Bayer, Janssen Oncology, Roche, Merck, Bristol-Myers Squibb, AstraZeneca, Pfizer, GlaxoSmithKline; research funding from Boehringer Ingelheim, Janssen-Cilag, Pierre Fabre; and travel, accommodations, expenses from Janssen-Cilag, Bayer, Boehringer Ingelheim, Pierre Fabre, Pfizer, Roche, MSD Oncology. JPM has received honoraria for consulting or advisory role from Sanofi, Janssen, Astellas, and Bayer. MÁC reports consulting role for BMS, MSD, Bayer, EUNSA, Pfizer, Roche, Janssen, Pierre Fabre, Ipsen; honoraria from BMS, Astellas, Janssen, MSD, Sanofi, Bayer, Roche, Pfizer, Novartis, Ipsen; travel/accommodation expenses from Janssen, Astellas, Roche, Ipsen, MSD. NC has received institutional research funding from Roche, AstraZeneca, Redx, Janssen, Pfizer, Taiho, Eisai, Avacta, UCB, Starpharma, Boehringer, Stemline, and Orion; and has participated on a data safety monitoring board or advisory board for Roche, RedX Pharmaceuticals, and Jannsen. C-CL reports receiving personal fees from AbbVie, Bayer, BeiGene, Blueprint Medicines, Bristol-Myers Squibb, Daiichi Sankyo, Eli Lilly, Merck KGaA, Novartis, PharmaEngine, and Roche. DB reports personal fees from Pfizer and Janssen. MB, LS and TB report being employees of Boehringer Ingelheim. JdB has received personal fees and travel expenses for serving as an advisor for Amgen, Astellas, AstraZeneca, Bayer, BioXcel Therapeutics, Boehringer Ingelheim, CellCentric, Daiichi, Eisai, Roche/Genentech, Genmab, GlaxoSmithKline, Harpoon, Janssen, Menarini Silicon Biosystems, Merck Serono, Merck Sharp & Dohme, Orion Pharma, Pfizer Inc., Qiagen, Sanofi Aventis, Sierra Oncology, Taiho, Terumo, and Vertex Pharmaceuticals; has received grants paid to his institution from Astellas, AstraZeneca, Bayer, CellCentric, Daiichi, Roche/Genentech, Genmab, GlaxoSmithKline, Harpoon, Janssen, Merck Serono, Merck Sharp & Dohme, Orion Pharma, Pfizer Inc., Sanofi Aventis, Sierra Oncology, Taiho, and Vertex Pharmaceuticals; and holds patents WO 2005 053662 licensed to AstraZeneca and US5604213 licensed to Janssen, for which he receives no personal income. SL, RHJ and S-SW declare no competing interests."

"Funding This study was funded by Boehringer Ingelheim. Boehringer Ingelheim was given the opportunity to review the manuscript for medical and scientific accuracy, as well as intellectual property considerations. The authors were fully responsible for all content and editorial decisions, were involved at all stages of manuscript development and have approved the final version. The authors did not receive payment related to the development of the manuscript."

"Clinical trial registration EudraCT number 2013-004011-41."