Real-world effectiveness, satisfaction, and optimization of ubrogepant for the acute treatment of migraine in combination with onabotulinumtoxinA: results from the COURAGE Study.

"Declarations Ethics approval and consent to participateRespondents were required to provide written informed consent online. Participants were informed that their personal de-identified study-related data would be used in accordance with local privacy and data protection laws. The study protocol was approved by Advarra Institutional Review Board in the United States. Consent for publicationNot applicable. Competing interestsRBL has received research support from the National Institutes of Health, the FDA, and the National Headache Foundation. He serves as consultant, advisory board member, or has received honoraria or research support from AbbVie/Allergan, Amgen, Biohaven, Dr. Reddy’s Laboratories (Promius), electroCore, Eli Lilly, GlaxoSmithKline, Lundbeck, Merck, Novartis, Teva, Vector, and Vedanta Research. He receives royalties from Wolff’s Headache, 8th edition (Oxford University Press, 2009), and Informa. He holds stock in Biohaven and Manistee.EE, NDA, and DS were employees of OPEN Health Group at the time of study conduct.LD serves as a consultant, advisory board member, or has received honoraria from AbbVie, Amgen, Eli Lilly, Novartis, and Teva.AMA, JC-DL, and KS are employees of AbbVie and may hold AbbVie stock.SH serves as a consultant, advisory board member, or has received honoraria from AbbVie, Amgen, Biohaven, Currax, Eli Lilly, Impel, Lundbeck, Novartis, Teva, Theranica, and Upsher-Smith. Competing interests RBL has received research support from the National Institutes of Health, the FDA, and the National Headache Foundation. He serves as consultant, advisory board member, or has received honoraria or research support from AbbVie/Allergan, Amgen, Biohaven, Dr. Reddy’s Laboratories (Promius), electroCore, Eli Lilly, GlaxoSmithKline, Lundbeck, Merck, Novartis, Teva, Vector, and Vedanta Research. He receives royalties from Wolff’s Headache, 8th edition (Oxford University Press, 2009), and Informa. He holds stock in Biohaven and Manistee. EE, NDA, and DS were employees of OPEN Health Group at the time of study conduct. LD serves as a consultant, advisory board member, or has received honoraria from AbbVie, Amgen, Eli Lilly, Novartis, and Teva. AMA, JC-DL, and KS are employees of AbbVie and may hold AbbVie stock. SH serves as a consultant, advisory board member, or has received honoraria from AbbVie, Amgen, Biohaven, Currax, Eli Lilly, Impel, Lundbeck, Novartis, Teva, Theranica, and Upsher-Smith."

"Funding Allergan (prior to its acquisition by AbbVie) funded this study and participated in the study design, research, analysis, data collection, interpretation of data, reviewing, and approval of the publication. All authors had access to relevant data and participated in the drafting, review, and approval of this publication. No honoraria or payments were made for authorship."