A human antibody epitope map of the malaria vaccine antigen Pfs25.

"data availability atomic coordinates and structure factors have been deposited in the protein data bank under the following accession numbers: 8ezk pfs25 in complex with as01-04; 8ezl pfs25 in complex with as01-50; 8ezm pfs25 in complex with as01-63. data availability atomic coordinates and structure factors have been deposited in the protein data bank under the following accession numbers: 8ezk"

"Competing interests The authors declare no competing interests."

"We thank PATH’s Malaria Vaccine Initiative for funding and collaborative support by Virginia Price, C. Richter King, Randall MacGill, and Yimin Wu for BCR analysis, hmAb production and characterization. The authors thank J. Patrick Gorres for assistance in editing and manuscript preparation. We thank the staff members of SER-CAT and GM/CA beamlines at the Advanced Photon Source, Argonne National Laboratory for beamline supports. Data were collected at Southeast Regional Collaborative Access Team (SER-CAT) 22-ID (or 22-BM) beamline at the Advanced Photon Source, Argonne National Laboratory. SER-CAT is supported by its member institutions, and equipment grants (S10_RR25528, S10_RR028976 and S10_OD027000) from the National Institutes of Health. GM/CA@APS has been funded in whole or in part with Federal funds from the National Cancer Institute (ACB-12002) and the National Institute of General Medical Sciences (AGM-12006). This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility, operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. The Eiger 16 M detector at GM/CA-XSD was funded by NIH grant S10 OD012289. This study used the Office of Cyber Infrastructure and Computational Biology (OCICB) High Performance Computing (HPC) cluster at the National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD. This work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by grant 01665623-GEN from PATH’s Malaria Vaccine Initiative to PED for BCR analysis and hmAb production."