Cartilage-specific <i>Sirt6</i> deficiency represses IGF-1 and enhances osteoarthritis severity in mice.

"detailed experimental procedures and analyses are provided in online supplemental file 10 1136/ard-2023-224385 supp1 supplementary data as global loss of sirt6 in mice results in death within 4 weeks of age we generated inducible cartilage-specific sirt6- deficient mice ( sirt6 fl/fl ;aggrecan-cre ert2 ( sirt6 cko)) and compared them with sirt6 intact littermate controls ( sirt6 fl/fl ).; rna-sequencing dat are available at geo accession gse235082. data availability statement data are available on reasonable request. rna-sequencing dat are available at geo accession gse235082"

"Competing interests: None declared."

"Funding: This research was conducted while JC was an Irene Diamond Fund/AFAR Postdoctoral Transition Awardee in Aging. This study was also funded by grants from the National Institute on Aging R03AG070535, R01AG078609 (JC) and R01AG044034 (RFL) and in part by the Klaus Kuettner Endowed Chair for Osteoarthritis Research (SC)."